Process for the expression of foreign genes in yeasts

Details Process for the expression of foreign genes in yeasts Process for the expression of foreign genes in yeasts

C - Chemistry, Metallurgy

12

P

195/1.29

C12P 1/02 (2006.01) C12N 9/10 (2006.01) C12N 15/81 (2006.01)

Patent

CA 2031810

- 1 - Abstract of the Disclosure A process for the expression of foreign genes in yeasts The invention relates to the optimization of the expres- sion of foreign genes, especially recombinant factor XIIIa (rFXIIIa) in yeasts. The optimization was essen- tially carried out by use of a hybrid Gal UAS /CycI promoter, deletion of the 5' non-translated region and truncation of the 3' non-translated region of the FXIIIa cDNA, selection of specific yeast strains and a par- ticularly suitable growth medium composed of whey or whey hydroly ate. Quantities achievable in this way are ? 100 mg/l FXIIIa in shake cultures and ? 500 mg/l in fermentation after scale-up.

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