A - Human Necessities – 61 – P
Patent
A - Human Necessities
61
P
A61P 25/00 (2006.01) A61P 21/02 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) B01D 11/02 (2006.01)
Patent
CA 2379395
A process for preparing a pharmaceutically-active extract of the root of a plant of the family Valerianacae, specifically, <i>Valeriana officinalis</i> L., is described. This process comprises the steps of adding the roots to an alcoholic extraction solvent to form a mixture, wherein the alcoholic extraction solvent comprises between approximately 50 % to approximately 100 % (v/v) in a remainder of water, and heating the mixture to a temperature of between approximately 70 ~C to approximately 80 ~C for a period of at least approximately two hours. By this process valerenic acid is obtained in the extract, and the extract has a content of valepotriates and valepotriate degradation products or derivatives that is substantially reduced with respect to the content of valepotriates in the roots, and has a content of valerenic acids that is not substantially reduced with respect to the content of valerenic acids in the roots. Also preferably, the content of volatile oils in the extract is also not substantially with respect to the content of volatile oils in the roots. A pharmaceutically-active extract of the root of a plant of the family Valerianaceae is also described. This extract is obtained by a process comprising the steps of adding the roots to an alcoholic extraction solvent to form a mixture, wherein the alcoholic extraction solvent comprises between approximately 50 % (v/v) to approximately 100 % (v/v) in a remainder of water, and heating the mixture to a temperature of between approximately 70 ~C to approximately 80 ~C for a period of at least approximately two hours. This extract may be used in the formulation of an ingestible form, preferably exhibiting sedative and/or muscle relaxant, and/or anxiolytic activity.
L'invention porte sur un procédé de préparation d'un extrait à activité pharmaceutique de racines d'une plante de la famille des <i>Valerianacae</i>, et spécifiquement de la <i>Valeriana officinalis</i>. Ledit procédé consiste à en ajouter les racines à un solvant alcoolique d'extraction pour former un mélange, ledit solvant contenant 50 % à environ 100 % (v/v) d'éthanol et le reliquat d'eau, puis à chauffer le mélange à une température comprise entre environ 70 ·C et environ 80 ·C pendant au moins environ deux heures. On obtient ainsi un extrait contenant des acides valéréniques d'une teneur en valépotriate et en produits de dégradation ou dérivés du valépotriate relativement réduite par rapport à celle des racines, alors que la teneur en acide valérénique et en huiles volatiles ne l'est pas. L'invention porte également sur le susdit extrait à activité pharmaceutique de racines d'une plante de la famille des <i>Valerianacae</i> obtenu par un procédé consistant à en ajouter les racines à un solvant alcoolique d'extraction pour former un mélange, ledit solvant contenant 50 % à 100 % (v/v) d'éthanol et le reliquat d'eau, puis à chauffer le mélange à une température comprise entre environ 70 ·C et environ 80 ·C pendant au moins environ deux heures. Cet extrait peut servir à la préparation d'une forme ingérable présentant de préférence une activité sédative et/ou de relâchement musculaire et/ou anxiolytique.
Andrews Michael J.
Basu Amaresh
Ancile Pharmaceuticals Inc.
Barrigar Intellectual Property Law
LandOfFree
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