Process for the fermentative production of erythropoietin

Details Process for the fermentative production of erythropoietin Process for the fermentative production of erythropoietin

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01)

Patent

CA 2727045

The present invention relates to a process for the fermentative continuous production of erythropoietin, where eu-karyotic erythropoietin-producing cells are cultured in a perfusion reactor while retaining the cells, the glucose concentration in the culture supernatant being adjusted via the perfusion rate and the cell number via the cell retention rate and/or the outward transferral of defined amounts of cell-containing culture medium from the bioreactor within preset zones.

L'invention concerne un procédé de production en continu, par fermentation, d'érythropoïétine, caractérisé en ce que des cellules productrices d'érythropoïétine eucaryotes sont cultivées dans un réacteur à perfusion avec teneur résiduaire des cellules, et en ce que la concentration en glucose dans la fraction des cultures est ajustée supérieure à la vitesse de perfusion, et le nombre de cellules est ajusté supérieur au taux de retenue des cellules et/ou en ce que le rejet, du bioréacteur, de quantités définies en milieu de culture cellulaire, est réglé à l'intérieur de domaines prédéterminés.

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