Process for the glycosylation of avermectin agylcones

Details Process for the glycosylation of avermectin agylcones Process for the glycosylation of avermectin agylcones

C - Chemistry, Metallurgy

12

P

C12P 19/62 (2006.01) C07D 493/22 (2006.01) C07H 17/08 (2006.01) C07H 19/01 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2044875

30/DLR28 18088 TITLE OF THE INVENTION PROCESS FOR THE GLYCOSYLATION OF AVERMECTIN AGYLCONES ABSTRACT OF THE DISCLOSURE Avermectin aglycones are glycosylated by fermentation in a medium of a non-producing mutant of Streptomyces avermitilis MA-6078. The glycosylation produces the monosaccharide and disaccharide derivatives while leaving the remainder of the molecule intact. The microorganism glycosylates with the .alpha.-L-oleandrose moiety.

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