G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2611365
The present invention relates to methods for the characterization of enzymes or of enzyme-compound complexes, wherein the enzyme is obtained from a protein preparation with the help of at least one broad spectrum ligand immobilized on a solid support and wherein the enzyme is characterized by mass spectrometry. These methods are useful for the screening of non-immobilized compound libraries, selectivity profiling of lead compounds and mechanism of action studies in living cells.
La présente invention concerne des méthodes de caractérisation d'enzymes ou de complexes d'enzymes et de composés, l'enzyme étant obtenue à partir d'une préparation protéique à l'aide d'au moins un ligand à large spectre immobilisé sur un support solide et l'enzyme étant caractérisé par spectrométrie de masse. Lesdites méthodes sont utiles pour le criblage de bibliothèques de composés non immobilisés, pour la détermination du profil de sélectivité de têtes de série et pour des études du mécanisme d'action dans des cellules vivantes.
Bantscheff Marcus
Drewes Gerard
Eberhard Dirk
Hopf Carsten
Kruse Ulrich
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cellzome Ag
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