Process for the in-solvent, in-situ generation of haloalkyl...

Details Process for the in-solvent, in-situ generation of haloalkyl... Process for the in-solvent, in-situ generation of haloalkyl...

C - Chemistry, Metallurgy

07

D

260/368, 260/358

C07D 309/06 (2006.01) C07D 307/16 (2006.01) C07C 103/38 (1980.01)

Patent

CA 1165325

Abstract of the Disclosure The present invention is directed to a process for the preparation of certin N-substituted -2-haloacetanilides via the reaction of a secondary 2-haloacetanilide with a halo- alkyl ether, particularly, halomethyl ethers, which comprises forming the ether in situ by the in-solvent reactin of an alcohol, formaldehyde or other aldehyde and an acid halide to produce high purity haloalkyl ethers, while decreasing the concentration of undesirable bis by products, as for example bis(chloromethyl) ether. The ether formed in situ thereafter reacts with the secondary 2-haloacetanilide in the presence of a phase transfer catalyst and base to form the N-substituted-2-haloacetanilide.

373352

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