C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/80 (2006.01) C12N 1/15 (2006.01) C12N 9/02 (2006.01) C12N 15/53 (2006.01) C12N 15/90 (2006.01) C12P 37/00 (2006.01)
Patent
CA 2258562
Process for inactivating genes which code for enzymes of the phenyl acetate catabolism, plasmids containing them and strains transformed therewith. The process applies preferably to the gene pahcA of A.nidulans and to the gene pahA of P. chrysogenum, genes which code respectively for competitor enzymes for this substrate with the biosynthetic enzymes of penicillin. The non expression of said enzymes favors the synthesis of this antibiotic, increasing its production, with a smaller demand of phenyl acetate per culture unit.
Procédé d'inactivation de gènes codant pour des enzymes du catabolisme de phénilacétate, plasmides les contenant et souches transformées avec ceux-ci. Le procédé s'applique de préférence au gène phacA d'A. nidulans et au gène pahA de P.chrysogenum, gènes codant respectivement pour des enzymes qui se disputent avec les enzymes biosynthétiques de pénicilline ce substrat. La non expression des ces enzymes favorise la synthèse de cet antibiotique, en augmentant sa production, avec une demande réduite de phénilacétate par unité de culture.
Barredo Fuente Jose Luis
Diez Garcia Bruno
Fernandez Canon Jose Manuel
Maldonado Francisco Salto
Mingot Ascencao Jose Manuel
Antibioticos S.a.
Mccarthy Tetrault Llp
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