Process for the intensification of microbiological...

C - Chemistry – Metallurgy – 12 – P

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C12P 33/00 (2006.01) C12P 1/00 (2006.01) C12P 33/02 (2006.01) C12P 33/08 (2006.01)

Patent

CA 1185548

A B S T R A C T Microbiological conversions of cyclodextrins are intensified by adding to the reaction mixture 0.2 to 3 moles of .alpha.-, .beta.- or .gamma. cyclodextrin or an optional mixture thereof pro mole of the steroid substrate, before, at the beginning or during the conversion. The cyclodextrin if desired, can be recovered after the reaction. In this way the reaction velocity can be increased, the reaction time is reduced, the substrate concentration in the solution, i.e. its solubility is increased or the so called product inhibition may be avoided. In certain cases of more alternatives the desired reaction can be catalysed and in this manner the selectivity is increased.

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