Process for the isolation of alkaloid components from the...

Details Process for the isolation of alkaloid components from the... Process for the isolation of alkaloid components from the...

C - Chemistry, Metallurgy

07

D

260/237.3, 260/2

C07D 471/22 (2006.01) C07D 471/20 (2006.01) C07D 519/04 (2006.01)

Patent

CA 1094552

ABSTRACT OF THE DISCLOSURE There is disclosed a new process for the isolation of alkaloid components from the plant Vinca rosea L. More particularly, the invention relates to a process for the large-scale isolation of native catharantine, vindoline and 3',4'-anhydrovinblastine whereby the isolation of vincristine, vinblastine, leurosine and the corresponding dosacetoxy, desacetyl and N-desmethyl derivatives in a manner known per se can also be accomplished. The alkaloids isolated according to the invention possess valuable biological activities, leurosine for instance has tumour inhibiting activity and the N- desmethyl-N-formyl derivative thereof is one of the most promising substances in the fight against leucemia.

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