Process for the isolation of lovastatin

Details Process for the isolation of lovastatin Process for the isolation of lovastatin

C - Chemistry, Metallurgy

12

P

C12P 17/06 (2006.01) C07D 309/30 (2006.01)

Patent

CA 2164411

There is disclosed a process for the isolation of the hypolipaemic active substance lovastatin from a sample, e.g. fermentation broth, mycelium or filtrate of Aspergillus terreus (ATCC 20542) or Aspergillus oryzae (ATCC 74135) by extraction with butyl acetate. Simultaneously with the concentration of the extract, lactonisation takes place. There follows a direct crystallization of lovastatin in the lactone form from butyl acetate.

Procédé d'isolement à partir d'un échantillon, et par extraction à l'aide de l'acétate de butyle, de la substance à activité hypolipémiante appelée lovastatine, ledit échantillon étant, par exemple, un bouillon de fermentation, un mycélium ou un filtrat de Aspergillus terreus (ATCC 20542) ou de Aspergillus oryzae (ATCC 74135). La lactonisation se produit en même temps que la concentration de l'extrait. Ensuite, il se produit une cristallisation directe de lovastatine sous forme de lactone à partir de l'acétate de butyle.

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