Process for the isolation of lovastatin

Details Process for the isolation of lovastatin Process for the isolation of lovastatin

C - Chemistry, Metallurgy

07

C

C07C 67/02 (2006.01) C07C 67/60 (2006.01) C07D 309/30 (2006.01) C12P 17/00 (2006.01) C12P 17/02 (2006.01) C12P 17/06 (2006.01)

Patent

CA 2412566

The process for the preparation and isolation of the hypolipaemic active substance lovastatin in substantially pure form having a purity of at least 95% which comprises lactonizing the mevinolinic acid to lovastatin in a totally aqueous medium.

L'invention concerne un procédé de préparation et d'isolation de lovastatine (substance hypolipaémique active) sous forme essentiellement pure avec une pureté d'au moins 95 %. Ledit procédé consiste à lactoniser l'acide mévinolinique en lovastatine dans un mileu totalement aqueux.

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