Process for the isolation of purified gangliosides from...

Details Process for the isolation of purified gangliosides from... Process for the isolation of purified gangliosides from...

C - Chemistry, Metallurgy

07

H

260/230.58

C07H 15/10 (2006.01) C07D 309/00 (2006.01) C07D 309/02 (2006.01)

Patent

CA 2002155

68477-4 ABSTRACT The invention relates to a process for the isolation and purification from ganglioside-containing living tissue of gangliosides having a salic acid content of more than 30% by weight which comprises dehydrating macerated tissue, extracting the dehydrated tissue as a powder with a chloroform-methanol mixture, extracting the chloroform-methanol fraction with saline, separating from the extract thus obtained a methanol- saline fraction, loading said methanol-saline fraction on to a column filled with silica gel having non-polar functional groups, i.e. reverse-phase silica gel, packed within a solvent, washing said column with an organic solvent, eluting the de- sired gangliosides from said column employing organic solvents of different polarities and recovering the purified ganglio- sides from said organic solvents.

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