Process for the loading of water-swellable water- insoluble...

Details Process for the loading of water-swellable water- insoluble... Process for the loading of water-swellable water- insoluble...

A - Human Necessities

61

K

167/197

A61K 31/57 (2006.01) A61K 9/14 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1240928

ABSTRACT TITLE : "PROCESS FOR THE LOADING OF WATER-SWELLABLE WATER- -INSOLUBLE POLYMERS WITH MEDROXYPROGESTERONE ACETATE" A water-swellable, water-insoluble polymer is loaded with methylhydroxyprogesterone acetate (MAP) by: (a) preparing and grinding a mixture of a said polymer and MAP; or (b)(i) preparing a mixture of a said polymer which is stable under the heating to which the mixture is subjected in step (ii) and MAP and (ii) heating the mixture up to the melting temperature of MAP; or (c) swelling a said polymer with a MAP solution capable thereof and drying the resulting swollen polymer/MAP system. The MAP loaded polymer is useful as a pharmaceutical composition.

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