C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/08 (2006.01) C07D 209/44 (2006.01) C07D 307/79 (2006.01) C07D 307/87 (2006.01) C07D 333/54 (2006.01) C07D 333/72 (2006.01) C07D 405/08 (2006.01)
Patent
CA 2683512
The current invention describes novel chiral synthetic routes and intermediates for the manufacture of chiral anti-inflammatory agents of general formula (VIII) in which at least one of the groups X1, X2, X3 is selected from fluoro, chloro, bromo, hydroxy, methoxy, ethoxy, trifluoromethyl, amino whereas the other groups X1, X2, X3 have the meaning of a hydrogen atom, in which at least one of the groups Z1, Z2, Z3 is selected from -O-, -S-, -NH-, -N(-CH3)-, whereas the other groups Z1, Z2, Z3 have the meaning of a -CH2- group, and in which Ar is an aromatic group.
La présente invention décrit de nouvelles voies de synthèse chirale et des intermédiaires pour la fabrication d'agents anti-inflammatoires chiraux de formule générale (VIII) où au moins l'un des groupes X1, X2, X3 est choisi parmi fluoro, chloro, bromo, hydroxy, méthoxy, éthoxy, trifluorométhyle, amino, alors que les autres groupes X1, X2, X3 ont la signification d'un atome d'hydrogène, où au moins l'un des groupes Z1, Z2, Z3 étant choisi parmi -O-, -S-, -NH-, -N(-CH3)-, alors que les autres groupes Z1, Z2, Z3 ont la signification d'un groupe -CH2-, et où Ar est un groupe aromatique.
Intendis Gmbh
Marks & Clerk
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