Process for the manufacture of...

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C - Chemistry, Metallurgy

07

D

C07D 207/14 (2006.01) C07D 203/24 (2006.01)

Patent

CA 2133091

A novel process for preparing a stereospecific (S)-3-amino-1-substituted pyrrolidine used as a key intermediate in preparing quinolone and naphthyridone antibacterial agents where the 7- position is occupied with a stereospecific 3-amino-pyrrolidine side chain is described starting from inexpensive L-aspartic acid. L-aspartic acid is converted to the desired (S)-3-aminopyrrolidine via a novel, high yield transformation of a substituted aziridine.

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