Process for the manufacture of a composite material

Details Process for the manufacture of a composite material Process for the manufacture of a composite material

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61F 2/14 (2006.01) A61L 27/34 (2006.01) A61L 31/10 (2006.01) C08J 7/04 (2006.01) C08J 7/12 (2006.01) C09D 177/04 (2006.01) C09D 189/00 (2006.01) C12P 21/00 (2006.01) G02B 1/04 (2006.01) G02C 7/04 (2006.01)

Patent

CA 2675195

The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking said water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.

La présente invention concerne un procédé de fabrication de matériaux composites comprenant les étapes consistant à (a) fournir un matériau organique hydrophobe en vrac, et (b) appliquer un revêtement de surface hydrophile sur le matériau organique hydrophobe en vrac d'abord en fixant de manière non covalente à la surface du matériau en vrac un peptide soluble dans l'eau comprenant une fraction hydrophobe ; puis en réticulant chimiquement ou enzymatiquement ledit peptide soluble dans l'eau. Les matériaux composites fabriqués selon le procédé de l'invention ont des caractéristiques souhaitables relativement à l'adhérence, à la durabilité, à l'hydrophilie, à la mouillabilité, à la biocompatibilité et à la perméabilité du substrat et sont ainsi particulièrement utiles en tant que des dispositifs ophtalmiques.

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