Process for the manufacture of a tricyclic compound

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/04 (2006.01) C07C 243/28 (2006.01) C07D 215/58 (2006.01) C07D 498/06 (2006.01)

Patent

CA 2153984

A process for preparing a compound of formula (1) or a phamaceutically- acceptable salt thereof, comprising: 1) reacting a compound of formula (III), in which R is a straight or branched chain alkyl having from one to four carbon atoms, with an alkali metal hydroxide in an aqueous medium at a temperature of about 80 to 120 ° C and a time of about 20 to 100 hours to form a reaction product; 2) cyclizing the reaction product of step 1) with formic acid and formaldehyde to form a formiate compound; and 3) neutralizing the formiate compound of step 2) with an aqueous base.

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