C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/241.31
C07D 223/28 (2006.01) C07D 223/22 (2006.01)
Patent
CA 1163993
4-12576/= Process for the manufacture of an oxo compound and new intermediates required therefor, Abstract The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz- [b,f] azepine of the formula Image ( I I I ) which comprises a) nitrating 5-cyano-5H-dibenz[b,f]azepine of the formula I so to obtain 5-cyano-10-nitro 5H-dibenz[b,f]azepine, b) hydrolysing the 5-cyano group in the compound obtained so to obtain 5-carbamoyl-10-nitro-5H-dibenz[b,f] azepine, or c) reducing the 10-nitro-group in the compound obtained and hydrolysing the reduction product, or d) reducing the 10-nitro group in the compound of the formula II and hydrolysing the reduction product so to obtain 5-cyano-10-oxo-10,11-dihydro-5H-dibenz[b,f] of the formula V and hydrolysing the 5-cyano group in the compound obtained, or e) reducing the 10-nitro group in the compound 5-cyano 10- nitro-5H-dibenz[b,f]azepine so to obtain 5-cyano-10-iso- nitroso-10,11-dihydro-5H-dibenz[b,f]azepine, hydrolysing the 10-isonitroso-group in the compound obtained to the 10-oxo-group and hydrolysing the 5-cyano group in the compound obtained to the 5-carboxamido group. The invention relates also to new intermediates produced in these reactions.
363450
Fetherstonhaugh & Co.
Novartis Ag
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