Process for the manufacture of apolipoproteins from human...

Details Process for the manufacture of apolipoproteins from human... Process for the manufacture of apolipoproteins from human...

C - Chemistry, Metallurgy

07

K

167/114, 530/3.2

C07K 14/775 (2006.01) A61K 35/14 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1335077

Apolipoproteins are isolated from human blood plasma fractions which contain apolipoproteins by suspending these fractions in buffer solutions. The suspensions are subsequently incubated with a lower aliphatic alcohol, either with or without an organic solvent. The phase which containes the lipoproteins is separated and concentrated. The products obtained according to the procedure may be used primarily for the treatment of cardiovascular diseases, in particular hyper- cholesterolemia.

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