Process for the manufacture of cephalosporin derivatives

Details Process for the manufacture of cephalosporin derivatives Process for the manufacture of cephalosporin derivatives

C - Chemistry, Metallurgy

07

D

C07D 501/04 (2006.01) C07D 501/00 (2006.01) C07D 501/18 (2006.01) C07D 501/24 (2006.01)

Patent

CA 2313379

The present invention is concerned with a novel process for the manufacture of cephalosporin derivatives of the general formula Image wherein Rl, R2 and R are defined in the specification, the process is characterized in that it comprises converting a phosphonium salt of the general formula Image wherein R is as above and Ph represents phenyl, into the corresponding ylide of the general formula Image wherein R and Ph are as above, and reacting same with an aldehyde of the general formula Image wherein R1 and R2 are as above.

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