Process for the manufacture of ethanesulfonyl-piperidine...

Details Process for the manufacture of ethanesulfonyl-piperidine... Process for the manufacture of ethanesulfonyl-piperidine...

C - Chemistry, Metallurgy

07

D

C07D 211/42 (2006.01) C07D 211/74 (2006.01)

Patent

CA 2341010

The present invention relates to a new process for the preparation of compounds of the general formulae (see formula I-a) (see formula I-b) wherein R1- R4 are, independently from each other, hydrogen, halogen, hydroxy, amino, nitro, lower-alkyl-sulfonylamido, or acetamido; R5-R8 are, independently from each other hydrogen, lower-alkyl, halogen, trifluoromethyl or lower-alkoxy; and their pharmaceutically acceptable acid addition salts. The compounds of formulae I-a and I-b are NMDA (N-methyl-D-aspartate)- receptor-subtype selective blockers, which have a key function in modulating neuronal activity and plasticity which makes them key players in mediating processes underlying development of CNS including learning and memory formation and function.

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