Process for the manufacture of glucosamine derivatives

Details Process for the manufacture of glucosamine derivatives Process for the manufacture of glucosamine derivatives

C - Chemistry, Metallurgy

07

K

260/230, 530/9,

C07K 9/00 (2006.01) A61K 31/70 (2006.01) C07H 13/08 (2006.01)

Patent

CA 1262400

PROCESS FOR THE MANUFACTURE OF GLUCOSAMINE DERIVATIVES Abstract of the Disclosure A glucosamine derivative of the general formula Image (I) in which X denotes a carbonyl or sulphonyl group, R denotes an optionally substituted alkyl radical or an optionally substi- tuted carbocyclic aryl radical and, if X is the carbonyl group, also denotes an alkoxy or benzyloxy radical, R1 denotes hydro- gen, alkyl or an optionally substituted benzyl radical, R2 denotes hydrogen or Lower alkyl, R4 and R6 denote hydrogen, alkyl or an optionally substituted benzyl or an acyl radical, R7 denotes hydrogen, alkyl, hydroxymethyl, mercaptomethyl or phenyl, R8 denotes an optionally esterified or amidised carboxyl group and R9 denotes an optionally esterified or amidised carboxyl group, with the proviso that the optionally substituted alkyl radical R has more than 1 carbon atom if X denotes the carbonyl group and the radical R2 denotes methyl; or, if X denotes the carbonyl group, the radical R2 represents hydrogen and R8 and R9 each represent a carboxyl group, and its salts. They have immunity-boosting action.

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