C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01) C12N 5/078 (2010.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2467046
A process for the manufacture of human mononuclear phagocytic leukocytes comprises incubating monocytes isolated from a blood sample of an individual and skin segments from the same individual, removing the dermis segments from the incubation mixture and sedimenting the obtained activated mononuclear phagocytic leukocytes by centrifugation, washing and resuspending the activated phagocytic leukocytes in the medium, and evaluating the culture for its suitability for human administration. Cellular therapy products are made from the obtained cultures and are useful for promoting axonal regeneration in the CNS, wound healing and treatment of myocardial infarction.
L'invention concerne un procédé de fabrication de leucocytes phagocytaires mononucléaires humains consistant à incuber les monocytes isolés d'un échantillon sanguin d'un sujet et des fragments de peau du même sujet, à enlever les fragments de derme du mélange d'incubation et à sédimenter les leucocytes phagocytaires mononucléaires activés ainsi obtenus par centrifugation, lavage et resuspension des leucocytes phagocytaires activés dans le milieu, enfin à procéder à une évaluation pour savoir si la culture est appropriée pour être administrée à un humain. Des produits de thérapie cellulaire sont fabriqués à partir des cultures obtenues, lesquels produits de thérapie sont utiles pour la promotion de la régénérescence axonale dans le système nerveux central, la cicatrisation des plaies et le traitement de l'infarctus du myocarde.
Ash Issar
Eisenbach-Schwartz Michal
Fulga Valentin
Kleiner Bakimer Ronit
Heenan Blaikie Llp
Ltd. Yeda Research And Development Co.
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