Process for the manufacture of liquid filled capsules

Details Process for the manufacture of liquid filled capsules Process for the manufacture of liquid filled capsules

A - Human Necessities

61

J

A61J 3/07 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2350943

The present invention relates to a process for encapsulating a shear sensitive fill mass into a capsule, characterised in that said fill mass is heated and subsequently cooled, immediately prior to the encapsulation. The invention relates also to the capsules obtainable by the said process. The process according to the present invention enables to obtain capsules showing high and constant dissolution rates. The amount of active agent intake can be therefore reduced since the active agent itself is rapidly dissolved. The overall costs of the medicament are thereby also reduced. The high homogeneity (and therefore the high and constant dissolution rate) of the capsules produced with the process according to the present invention guarantees a reproducible bioavailability and therapeutic effect of the active agent which is contained in it.

L'invention concerne un procédé d'encapsulation d'une masse de remplissage sensible au cisaillement. Ce procédé est caractérisé en ce que ladite masse de remplissage est chauffée puis refroidie juste avant l'encapsulation. L'invention concerne également les capsules obtenues au moyen dudit procédé. Le procédé selon l'invention permet d'obtenir des capsules présentant des taux de dissolution élevés et constants. Etant donné que l'agent actif est lui-même rapidement dissout, la quantité d'absorption d'agent actif peut ainsi être réduite, tout comme les coûts généraux du médicament. La haute homogénéité (et, par conséquent, le taux de dissolution élevé et constant) des capsules produites selon ce procédé garantit une biodisponibilité reproductible ainsi qu'un effet thérapeutique de l'agent actif contenu dans ces capsules.

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