Process for the manufacture of novel benzodioxole derivatives

Details Process for the manufacture of novel benzodioxole derivatives Process for the manufacture of novel benzodioxole derivatives

C - Chemistry, Metallurgy

07

D

260/385, 260/351

C07D 317/68 (2006.01) C07C 45/46 (2006.01) C07C 45/67 (2006.01) C07C 45/68 (2006.01) C07C 49/84 (2006.01) C07D 317/46 (2006.01) C07D 405/00 (2006.01)

Patent

CA 1196646

Process for the manufacture of novel benzodioxole deriva- tives. Abstract The invention relates to processes for the manufac- ture of novel benzodioxole derivatives of the general formula I Image in which R1 represents an aromatic or heteroaromatic radical which is unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or trifluormethyl, alk represents an alkylene or alkylidene radical having a maximum of 5 carbon atoms, n represents 0 or 1, R2 and R3 each represents, independently of the other, hydrogen, lower alkyl, lower alkoxy or halogen, and A represents the radical O-R4, wherein R4 represent. hydrogen or an aliphatic or araliphatic hydrocarbon radical which is unsubstituted or substituted by halogen or lower alkoxy, or A represents the radical Image ' 2 ' in which either R5 and R6 each represents) inde- pendently of the other, hydrogen or lower alkyl, or R5 and R6, together with the adjacent nitrogen atom, represent unsubstituted or lower alkyl-substi- tuted tetra- to hexa-methyleneimino or 4-morpholinyl or a pharmaceutically acceptable salt of a compound of the general formula I in which A represents OR4 wherein R4 represents hydrogen, with a base or a pharmaceutically acceptable acid addition salt of compounds of the general formula I in which the radical R1 has a basic character. The novel substan- ces exhibit diuretic and, in addition, uricosuric activity and may be used, preferably in the form of appropriate pharmaceutical compositions, for the treatment of oedema and hypertension.

401597

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