C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/389.7, 260/5
C07D 295/18 (2006.01) C07C 29/36 (2006.01) C07C 43/225 (2006.01) C07C 43/23 (2006.01) C07C 45/63 (2006.01) C07C 45/71 (2006.01) C07D 209/48 (2006.01) C07D 265/22 (2006.01) C07D 303/04 (2006.01) C07D 303/22 (2006.01) C07D 303/34 (2006.01) C07D 317/58 (2006.01)
Patent
CA 1146575
Abstract Novel derivatives of 2-aminoethanol of the formula Image (I) in which Ar represents optionally substituted phenyl, m represents a number from 0 to 3, n represents the number 0 or 1, and alk represents alkylene having 2 ot 5 carbon atoms, the nitrogen atom and the oxygen atom or, if n is 0, the phenyl radical, being separated from each other by at least two carbon atoms, and R1 and R2 each represents, independently of the other, hydrogen or lower alkyl, or together represent lower alkylene, oxa-lower alkylene, thia-lower alkylene, aza-lower alkylene or N- lower alkyl-aza-lower alkylene, with the proviso that, if m is 0, the phenyl radical Ar contains at least one substituent and a phenyl radical Ar that is substituted by one or two hydroxy groups or protected hydroxy groups contains at least one additional substituent which is different from those substituents, in the form of racemic mixtures, racemates, optical anti- podes or salts thereof. Compounds of this kind act to some extent as blockers and to some extent as stimulators of .beta.-adrenergic receptors with more or less pronounced cardio- selectivity and can accordingly be used, on the one hand, in the indications customary for .beta.-blockers and, on the other hand, for the treatment of insufficient heart output, asthma and circulatory disorders.
365897
Fuhrer Walter
Ostermayer Franz
Zimmermann Markus
Fetherstonhaugh & Co.
Novartis Ag
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