C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/233, 260/308
C07F 9/547 (2006.01) A61K 31/675 (2006.01) C07F 9/6503 (2006.01) C07F 9/6506 (2006.01) C07F 9/6518 (2006.01) C07F 9/6539 (2006.01)
Patent
CA 1338937
Alkanediphosphonic acids, in particular heteroarylalkanediphosphonic acids of formula Image (I) wherein R1 is a 5-membered heteroaryl radical which may be fused with benzene or cyclohexene nuclei and which contains, as hetero atoms, 2 to 4 N-atoms or 1 or 2 N-atoms as well as 1 O- or S-atom, and which is unsubstituted or C-substituted by lower alkyl, phenyl or phenyl which is substituted by lower alkyl, lower alkoxy and/or halogen, or by lower alkoxy, hydroxy, di-lower alkylamino, lower alkylthio and/or halogen, and/or is N-substituted at a N-atom which is capable of substitution by lower alkyl, lower alkoxy and/or halogen, and R2 is hydrogen, hydroxy, amino, lower alkylthio or halogen, and salts thereof, have regulatory action on calcium metabolism and can be used as medicaments for the treatment of diseases associated with impairment of calcium metabolism. The compounds are obtained for example by converting, in a compound of formula Image (II), wherein X1 is a functionally modified phosphono group and X2 is a free or functionally modified phosphono group, X1 and, if appropriate X2, into the free phosphono group.
552209
Jaeggi Knut A.
Widler Leo
Fetherstonhaugh & Co.
Jaeggi Knut A.
Novartis Ag
Widler Leo
LandOfFree
Process for the manufacture of novel substituted... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the manufacture of novel substituted..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the manufacture of novel substituted... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1330013