Process for the manufacture of persilylated peptides

Details Process for the manufacture of persilylated peptides Process for the manufacture of persilylated peptides

C - Chemistry, Metallurgy

07

K

C07K 1/107 (2006.01)

Patent

CA 2705693

Process for the manufacture of a persilylated peptide or peptide analog, which comprises (a) producing a persilylated peptide or persilylated peptide analogue by silylating a corresponding peptide by reaction with a silylating agent other than trimethylsilylcyanide and (b) reacting a compound of formula (I) X-A-COOH wherein X is an amino protecting group, A is an aminoacid, peptide or peptide analogue residue and -COOH designates an optionally activated carboxylic group, with a persilylated peptide or a persilylated peptide analogue containing from 4 to 15 aminoacids.

La présente invention concerne un procédé permettant de fabriquer un peptide ou un analogue peptidique persilylé, qui comprend (a) la production d'un peptide persilylé ou d'un analogue peptidique persilylé par silylation d'un peptide correspondant par réaction avec un agent de silylation autre que le cyanure de triméthylsilyle et (b) la mise en réaction d'un composé de formule (I) X-A-COOH dans laquelle X est un groupe protecteur aminé, A est un résidu d'acide aminé, de peptide ou d'analogue peptidique et -COOH désigne un groupe carboxylique facultativement activé, avec un peptide persilylé ou un analogue peptidique persilylé contenant de 4 à 15 acides aminés.

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