Process for the manufacture of powders of inhalable medicaments

Details Process for the manufacture of powders of inhalable medicaments Process for the manufacture of powders of inhalable medicaments

B - Operations, Transporting

01

J

B01J 2/06 (2006.01) A61K 9/16 (2006.01) B01D 9/00 (2006.01) B01F 13/00 (2006.01) B01J 19/00 (2006.01) B01J 19/10 (2006.01)

Patent

CA 2502502

The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactor(a) a segmented flow of that fluid comprised of discrete volumes; or(b) a fluid mixture being separated by discrete volumes of a separating fluid which is substantially immiscible with said fluid,characterized in that the crystallization is initiated by application of ultrasound.

Cette invention a trait à un procédé amélioré de fabrication de poudres pour un médicament pouvant être inhalé. Ce procédé a recours à la cristallisation d'un fluide sursaturé contenant le médicament. On fait passer par un réacteur tubulaire, (a), un courant segmenté de ce fluide constitué de volumes distincts ou, (b), un mélange fluidique séparé par les volumes distincts du fluide séparateur qui est quasiment immiscible avec ce fluide. Le procédé se caractérise par le fait que la cristallisation est amorcée par l'application d'ultrasons.

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