Process for the manufacture of quinoline derivatives

Details Process for the manufacture of quinoline derivatives Process for the manufacture of quinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/56 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2487329

A process for the preparation of the compounds of general formula (I); by reacting a quinoline-3-carboxylic acid ester derivative of formula A with an aniline derivative of formula B in a solvent selected from straight- or branch- chaineded alkanes and cycloalkanes or mixtures thereof with a boiling point between 80 and 200 C.

L'invention concerne une méthode de préparation de composés de formule générale (I), qui consiste à mettre en réaction un dérivé d'ester d'acide quinoline-3-carboxylique de formule A avec un dérivé d'aniline de formule B, dans un solvant choisi parmi des alcanes et des cycloalcanes à chaîne droite ou ramifiée ou leurs mélanges, le point d'ébullition étant compris entre 80 et 200 C.

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