Process for the manufacture of spiro-linked pyrrolidine-2,5...

C - Chemistry – Metallurgy – 07 – D

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260/243.26, 260/

C07D 471/20 (2006.01) C07D 498/20 (2006.01) C07D 513/20 (2006.01)

Patent

CA 1261326

ABSTRACT OF THE DISCLOSURE Novel processes are disclosed for the manufacture of spiro-linked pyrrolidine-2,5-diones of the formula; Image which have potent inhibitory effects on aldose reductase and are useful for the reduction and prevention of chronic diabetic complications. These processes are useful as improved and convenient methods for large scale manufacture.

541568

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