Process for the manufacture of substituted propionic acids

Details Process for the manufacture of substituted propionic acids Process for the manufacture of substituted propionic acids

C - Chemistry, Metallurgy

07

C

C07C 51/36 (2006.01) C07C 59/64 (2006.01) C07C 59/70 (2006.01) C07C 253/30 (2006.01) C07D 333/24 (2006.01) C07C 255/57 (2006.01)

Patent

CA 2594909

The invention concerns a process for the manufacture of substituted propionic acids comprising providing a substrate of formula (I): And subjecting the substrate to enantioselective hydrogenation under enantioselective hydrogenation conditions in the presence of an enantioselective hydrogenation catalyst comprising a catalyst ligand having a metallocene group with a chiral phosphorus or arsenic substituent to provide in enantiomeric excess a product of formula (II): or its enantiomer or if applicable its diastereomer.

L'invention concerne un procédé de fabrication d'acides propioniques substitués, consistant à préparer un substrat de formule (I) et à soumettre le substrat à une hydrogénation énantiosélective dans des conditions d'hydrogénation énantiosélective, en présence d'un catalyseur d'hydrogénation énantiosélectif comprenant un ligand catalyseur ayant un groupe métallocène présentant un substituant phosphore ou arsenic chiral, en vue d'obtenir, en excès énantiomère, un produit de formule (II), ou son énantiomère ou, si nécessaire, son diastéréomère.

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