Process for the manufacture of the calcium salt of...

Details Process for the manufacture of the calcium salt of... Process for the manufacture of the calcium salt of...

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) C07D 239/42 (2006.01)

Patent

CA 2543358

A process for the manufacture of the calcium salt of (E)-7-[4-(4-fluorophenyl)- 6-isopropyl-2-[methyl (methylsulfonyl) amino]pyrimidin-5-yl](3R,5S)-3,5- dihydroxyhept-6-enoic acid, useful as an HMGCoA reductase inhibitor, from a compound of the formula (7) wherein A is an acetal or ketal protecting group and R is alkyl, via isolated crystalline compounds of the formula (8) or of formula (10) is described. Crystalline intermediates of formulae 7, 8 and 10 are also described.

L'invention concerne un procédé de fabrication du sel de calcium de l'acide (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl (methylsulfonyl) amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoïque, utilisable en tant qu'inhibiteur de HMGCoA réductase, à partir du composé possédant la formule (7) dans lequel A est un groupe protecteur acétal ou cétal et R est un alkyle, via des composés cristallins isolés ayant la formule (8) ou la formule (10). Elle concerne aussi des intermédiaires cristallins des formules 7, 8 et 10.

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