Process for the manufacture of thiazole derivatives with...

Details Process for the manufacture of thiazole derivatives with... Process for the manufacture of thiazole derivatives with...

C - Chemistry, Metallurgy

07

D

C07D 277/32 (2006.01) A01N 43/78 (2006.01) A01N 43/88 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2426707

A process for the preparation of a compound of the formula (I) in which Q, Y, Z, R1, R2 are as defined in claim 1; in which a) a compound of the formula (II), in which X is a leaving group, is reacted with a halogenating agent to give a compound of the formula (III), in which W is a halogen atom; and b) the resulting compound of the formula (III) is reacted with a compound of the formula (IV), in which R1, R2, Y, Z and Q are as defined in claim 1; wherein the preparation of the compound of the formula (III) according to process stage a) involves a purification step in which the reaction mass which has formed is treated with water in the acidic pH range; a process for the preparation of a compound of the formula (III) according to the abovementioned process a), and the use of the compounds of the formulae (II), (III) and (IV) in a process as detailed above are described.

L'invention concerne un procédé de préparation d'un composé de formule (I) dans laquelle Q, Y, Z, R1 et R2 sont tels que définis dans la revendication 1, a) un composé de formule (II), dans laquelle X représente un groupe partant, est réagi avec un agent d'halogénation pour produire un composé de formule (III) dans laquelle W est un atome halogène, et b) le composé obtenu de formule (III) est réagi avec un composé de formule (IV) dans laquelle R1, R2, Y, Z et Q sont tels que définis dans la revendication 1. La préparation du composé de formule (III) selon l'étape a) implique une étape de purification dans laquelle la masse de réaction formée est traitée avec de l'eau à pH acide. L'invention concerne également un procédé de préparation d'un composé de formule (III) conformément au procédé précité a), et l'utilisation des composés de formule (II), (III), (IV) dans un procédé détaillé ci-dessus.

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