Process for the manufacture of thrombin inhibitors

Details Process for the manufacture of thrombin inhibitors Process for the manufacture of thrombin inhibitors

C - Chemistry, Metallurgy

12

N

195/1.2, 195/1.3

C12N 15/15 (2006.01) A61K 38/58 (2006.01) C07H 21/00 (2006.01) C07K 14/815 (2006.01) C07K 16/38 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 15/10 (2006.01) C12N 15/74 (2006.01) C12N 15/81 (2006.01)

Patent

CA 1341426

The invention relates to DNA sequences that code for the amino acid sequence of the thrombin inhibitor hirudin, hybrid vectors containing such DNA sequences, host cells transformed with such hybrid vectors, novel polypeptides with thrombin-inhibiting activity produced from such transformed host cells, processes for the manufacture of these DNA sequences, hybrid vectors and transformed host cells, and processes for the manu- facture of these thrombin-inhibitors using the trans- formed host cells. The hirudin compounds that can be produced according to the invention have valuable pharmacological properties.

483736

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