Process for the manufacturing of 7-ethyl-10-hydroxy...

Details Process for the manufacturing of 7-ethyl-10-hydroxy... Process for the manufacturing of 7-ethyl-10-hydroxy...

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01)

Patent

CA 2591081

The invention discloses the preparation method of 7-ethyl-l0- hydroxycamptothecin from 4-ethyl-7, 8-dihydro-4-hydroxy-lH-pyrano [3,4-f ] indolizine-3, 6,10 (4H) -trione and 1- (2-amino-5-hydroxyphenyl) -propan-1-one using high reaction temperature and fast heating to that temperature .

L'invention concerne un procédé de préparation de 7-éthyl-10-hydroxycamptothécine à partir de 4-éthyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione et 1-(2-amino-5-hydroxyphényle)-propane-1-one qui utilise une température de réaction supérieure et un chauffage plus rapide à cette température.

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