C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0784 (2010.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61P 37/02 (2006.01) C07H 21/02 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2457322
The invention provides a method of producing mature dendritic cells in vitro, which comprises the step of culturing the immature dendritic cells in the presence of a specifically configured high molecular weight double stranded RNA (dsRNA) polymer. The specifically configured high molecular weight dsRNA polymer is typically selected from the group comprising poly [I]:poly [CxU]; poly [I]:poly [GxU]; poly [A]: poly [UxC]; poly [A]:poly [UxG]; poly [U]:poly [AxC]; poly [U]:poly [IxU]; poly [C]:poly [GxA]; poly [C]:poly [GxU]; poly [G]:poly [CxA]; poly [G]:poly [CxU] and Ampligen, where x is on average a number from 3 to 40. The immature dendritic cells may be exposed to an antigen before they are matured, and a vaccine including the antigen-presenting mature dendritic cells can then be prepared. A method of treating cancer, a virus, parasite and microorganism is also disclosed.
L'invention concerne une méthode de production de cellules dendritiques in vitro, consistant à mettre en culture des cellules dendritiques immatures en présence d'un polymère ARN bicaténaire (dsARN) de poids moléculaire élevé spécifiquement configuré. Le polymère ARN bicaténaire de poids moléculaire élevé spécifiquement configuré est généralement sélectionné dans le groupe comprenant poly [I]:poly [CxU]; poly [I]:poly [GxU]; poly [A]: poly [UxC]; poly [A]:poly [UxG]; poly [U]:poly [AxC]; poly [U]:poly [IxU]; poly [C]:poly [GxA]; poly [C]:poly [GxU]; poly [G]:poly [CxA]; poly [G]:poly [CxU] et Ampligen, x étant en moyenne un nombre de 3 à 40. Les cellules dendritiques immatures peuvent être exposées à un antigène avant d'être matures, et un vaccin contenant les cellules dendritiques matures présentant l'antigène peut alors être préparé. L'invention concerne également une méthode de traitement du cancer, d'un virus, d'un parasite et d'un microorganisme.
Adams Malcolm
Donninger Cyril
Bioclones (proprietary) Limited
Gowling Lafleur Henderson Llp
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