C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/20, 195/1.22
C12N 15/53 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 9/04 (2006.01) C12P 33/00 (2006.01) C12P 33/06 (2006.01) C12P 33/18 (2006.01)
Patent
CA 1340563
Genetically engineered host cells are provided which are able to carry out simultaneously oxidations of steroids, preferably the simultaneous introduction of the 17.alpha.-hydroxyl and the C21-hydroxyl group. In particular the oxidation is carried out with cells into which DNA has been introduced which encodes for at least two proteins involved in the biological pathway of cholesterol to hydrocortisone. Suited host cells comprise species of Bacillus, Saccharomyces or Kluyveromyces. The new host cells are suited for biochemical oxidations of cholesterol, pregnenolone, progesterone and 17.alpha.-hydroxy-progesterone, which are intermediates in said biological pathway. The host cells are also useful for the ultimate preparation of a multigenic system for the one-step conversion of cholesterol into hydrocortisone.
612871
Selten Gerardus Cornelis Maria
Slijkhuis Harmen
Smaal Eric Bastiaan
Aventis Pharma S.a.
Robic
Selten Gerardus Cornelis Maria
Slijkhuis Harmen
Smaal Eric Bastiaan
LandOfFree
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