Process for the physical depolymerization of...

C - Chemistry – Metallurgy – 08 – B

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C08B 37/10 (2006.01) C08B 37/00 (2006.01) C08B 37/08 (2006.01)

Patent

CA 2488089

The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by Gel Permeation for obtaining the desired Molecular Weight.

L'invention concerne un procédé de dépolymérisation de glycosaminoglycanes caractérisé par l'utilisation de rayonnement de faisceau d'électrons, éventuellement en présence d'un composé organique sélectionné dans le groupe renfermant des éthers, des alcools, des aldéhydes, des amides et de l'acide formique. L'invention concerne également de l'héparine intermédiaire dépolymérisée obtenue au moyen de ce procédé. L'héparine intermédiaire dépolymérisée peut être dissoute dans une solution tampon et fractionnée par perméation sur gel, aux fins d'obtention du poids moléculaire souhaité.

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