Process for the preparation 3-aryl-2-hydroxypropionic acid...

Details Process for the preparation 3-aryl-2-hydroxypropionic acid... Process for the preparation 3-aryl-2-hydroxypropionic acid...

C - Chemistry, Metallurgy

07

C

C07C 309/66 (2006.01) A61K 31/19 (2006.01) C07C 303/30 (2006.01)

Patent

CA 2448658

A process for the preparation of a compound of formula (I) in which R represents H or an acid protecting group which comprises reacting a compound of formula (II) in which R is as previously def ined with a compound of formula (III) wherein X is a suitable le aving group in the presence of a base and a phase transfer catalyst at a temperature in the range 50~C to 150~C.

L'invention concerne un procédé de préparation d'un composé de formule I, où R représente H ou un groupe de protection d'acide destiné à faire réagir un composé de formule II, où R est comme décrit ci-dessus, avec un composé de formule III, où X est un groupe partant approprié, en présence d'un catalyseur de transfert de base et d'un catalyseur de transfert de phase, à une température comprise entre 50· C et 150· C.

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