C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/24 (2006.01)
Patent
CA 2245825
A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N,N'- 4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracurium besylate is precipitated.
Le procédé de production d'atracurium bésylate réduit sensiblement le niveau d'impuretés du produit final obtenu et évite l'utilisation répétée d'éther. Selon le procédé de l'invention, N, N'-4,10-dioxa-3,11-dioxotridécylène-1,13-bis-tétrahydropapavérine (composé 1), du benzènesulfonate de méthyle ainsi qu'une quantité catalytique d'une base insoluble dans un solvent sont combinés pour former un mélange de réaction qui est maintenu pendant une période de temps suffisante pour la formation d'atracurium bésylate. Le mélange de réaction est ensuite filtré afin d'éliminer la base insoluble puis l'atracurium bésylate est précipité.
Bhatia Ashok V.
Chamberlin Steven A.
Davis Deborah A.
Drengler Keith A.
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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