Process for the preparation in pure form of the protease...

Details Process for the preparation in pure form of the protease... Process for the preparation in pure form of the protease...

C - Chemistry, Metallurgy

12

N

C12N 9/50 (2006.01) A61K 38/43 (2006.01) B01D 15/08 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/56 (2006.01) G01N 33/573 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2315309

A process for the preparation in pure form of the protease activating blood clotting factor VII and/or its proenzyme by use of one or more affinity chromatography separation processes and/or fractional precipitation is described, in which the affinity chromatography separation process used is adsorption on - calcium phosphate/hydroxyapatite, - a hydrophobic matrix, - a chelate matrix, - a matrix on which heparin or a substance related to heparin, such as heparan sulfate or dextran sulfate, is immobilized, and/or - a matrix which is coated with an immobilized monoclonal or polyclonal antibody directed against the protein to be isolated, or its F(ab) or F(ab)2 fragments. A pharmaceutical preparation and a reagent are moreover described which contain the said protease and its proenzyme.

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