Process for the preparation of 1-(2-tetrahydrofuryl)-...

Details Process for the preparation of 1-(2-tetrahydrofuryl)-... Process for the preparation of 1-(2-tetrahydrofuryl)-...

C - Chemistry, Metallurgy

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C07D 405/04 (2006.01) A61K 31/505 (2006.01) C07D 239/00 (2006.01) C07D 239/10 (2006.01) C07D 239/30 (2006.01) C07D 239/54 (2006.01) C07D 307/22 (2006.01) C07D 307/04 (2006.01)

Patent

CA 1114376

PROCESS FOR THE PREPARATION OF 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL Abstract of the Disclosure: A process for efficiently preparing 1-(2-tetrahydrofuryl)- 5-fluorouracil useful as an antitumor agent or an antiviral agent which comprises reacting 5-fluorouracil with 2,3-dihydrofuran. This reaction proceeds advantageously in the presence of a reacti accelerator such as a Lewis acid in a polar solvent such as pyri- dine.

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