C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/325.1
C07D 207/16 (2006.01) C07C 53/19 (2006.01) C07C 53/50 (2006.01)
Patent
CA 1137499
ABSTRACT OF THE DISCLOSURE The invention relates to a novel process for the preparation of 1-[3-mercapto-/2S/-methylpropionyl]-pyrrolidine-/2S/-carboxylic acid through the N-acylation of L-proline. According to the process of the invention L-proline is acylated with a 3-halogen-2-methylpropionyl chloride of the formula III Image III wherein Hal is a halogen atom, preferably chlorine or bromine, the obtained 1-[3-halogen-/2S/-methylpropionyl]-pyrrolidine-/2S/-carboxylic acid, wherein Hal is as stated above, is reacted with an alkali thiosulfate or alkali trithio- carbonate and the reaction product is hydrolized with an acid. The process of the invention is very economical as compared with the known processes. The de- sired product is prepared from methacrylic acid in 4 reaction steps with a total yield of 25 per cent and from L-proline in 2 reaction steps with a total yield of 30 per cent.
366072
Bakonyi Anna
Fazekas Gabor
Fischer Janos
Rozsa Laszlo
Vago Pal
Egyt Gyogyszervegyeszeti Gyar
Fetherstonhaugh & Co.
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