C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/326
C07D 207/337 (2006.01) C07D 207/323 (2006.01) C07D 207/34 (2006.01) A61K 31/40 (2006.01)
Patent
CA 1188306
Abstract The invention relates to a new process for the preparation of 1-alkyl- or 1,4-dialkyl-1H-pyrrole- -2-acetic acid, esters of the general formula (I) Image (I) wherein R1 is hydrogen or an alkyl group having from 1 to 4 carbon atoms, R2 and R3 each independently represent an alkyl group having from 1 to 4 carbon atoms, by selective desalkoxycarbonylation of the corresponding 1-alkyl- and 1,4-dialkyl-3-alkoxycarbonyl-1H-pyrrole- -2-acetic acid esters of the general formula (II) Image (II) wherein R1, R2 and R3 have the same meaning as defined above, by heating in the presence of a concentrated mineral acid or an aliphatic or aromatic sulfonic acid. Compounds of the general formula (I) are known pharmaceutically active materials, which can - 2 - be prepared by this process in a single reaction step selectively, without the formation of by-products.
430840
Agai Eva
Domany Gyorgy
Harsanyi Kalman
Kruzics Anna
Major Piroska
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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