Process for the preparation of 1.alpha., 3.beta. - dihydroxy...

Details Process for the preparation of 1.alpha., 3.beta. - dihydroxy... Process for the preparation of 1.alpha., 3.beta. - dihydroxy...

C - Chemistry, Metallurgy

07

J

260/7, 204/91.08

C07J 9/00 (2006.01) A23K 1/16 (2006.01) A23K 1/165 (2006.01) A23L 1/30 (2006.01) A61K 31/59 (2006.01) C07C 35/17 (2006.01) C07C 35/32 (2006.01) C07C 401/00 (2006.01) C07G 13/00 (2006.01) C07J 75/00 (2006.01)

Patent

CA 1055011

ABSTRACT 1.alpha.,3.beta.-dihydroxy steroid-5-enes are prepared by the reduction of 1.alpha.-hydroxy- and 1.alpha.,2.alpha.-epoxy- steroid-4,6- diene-3-ones and corresponding 6-substituted steroid-4-en- 3-ones where the 6-substituent is a reductively eliminatable atom or group with an alkali metal/liquid ammonia or alkali metal/liquid amine reducing agent in the presence of a proton source. The conversion of such dihydroxylated steroids to therapeutically useful new 1.alpha.-hydroxy vitamin D derivatives and related compounds is also described, as are pharmaceutical compositions and applications of these new compounds.

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