Process for the preparation of 1-aminopiperidine derivatives

Details Process for the preparation of 1-aminopiperidine derivatives Process for the preparation of 1-aminopiperidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 295/22 (2006.01) C07D 211/98 (2006.01)

Patent

CA 2600633

The present invention relates to a process for the preparation of compounds of the general formula (I). These are used as important intermediates in the preparation of bioactive substances. Preparation is carried out starting from dicarbonyl compounds of the general formula (II), which are reacted with appropriate hydrazine derivatives of the general formula (III) and subsequently hydrogenated. The present invention also relates to advantageous intermediate compounds.

L'invention concerne un procédé de préparation de composés représentés par la formule générale (I), qui constituent des produits intermédiaires importants dans la préparation de matières bioactives. Le procédé de préparation est mis en oeuvre à partir de composés dicarbonyle représentés par la formule générale (II), qui sont mis à réagir avec des dérivés d'hydrazine appropriés représentés par la formule générale (III), et ultérieurement hydrogénés. L'invention concerne aussi des composés intermédiaires avantageux.

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