Process for the preparation of 1-naphtyl-acetic acid...

Details Process for the preparation of 1-naphtyl-acetic acid... Process for the preparation of 1-naphtyl-acetic acid...

C - Chemistry, Metallurgy

07

C

260/472.3, 260/5

C07C 63/337 (2006.01) C07C 57/40 (2006.01) C07C 59/84 (2006.01) C07C 59/86 (2006.01) C07C 69/76 (2006.01)

Patent

CA 1100989

ABSTRACT OF THE DISCLOSURE. This invention relates to a process for the preparation of 1-naphthyl acetic acid derivatives having the general formula : Image (I) in which : R1 is a hydrogen atom or a straight- or branched-chain C1-6 alkyl group, R2 is a straight- or branched-chain alkyl group or a cycloalkyl group having 1-12 carbon atoms, A is a carbonyl or methylene group, R3 is a hydroxy group, a C1-6 straight- or branched-chain alkoxy group or a group of the formula NR4R5 in which R4 and R5 represent independently a hydrogen atom or, C1-6 straight- or branched-chain alkyl group or, together with the nitrogen atom to which they are attached, form a saturated or unsatu- rated heterocyclic radical, and their pharmaceutically acceptable salts. Said compounds have, in particular, anti-inflammatory, anti-pyretic and analgesic activities and are free from ulcerogenic activity under the administration conditions.

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