Process for the preparation of (1-oxo-2-phenyl, halophenyl...

Details Process for the preparation of (1-oxo-2-phenyl, halophenyl... Process for the preparation of (1-oxo-2-phenyl, halophenyl...

C - Chemistry, Metallurgy

07

D

260/472.2, 260/3

C07D 333/22 (2006.01) C07C 45/46 (2006.01) C07C 45/67 (2006.01) C07C 49/747 (2006.01) C07C 49/755 (2006.01) C07C 69/76 (2006.01)

Patent

CA 1038396

ABSTRACT OF THE DISCLOSURE (1-Oxo-2-phenyl, halophenyl or thienyl-2-methyl 6,7-dichloro-5-indanyloxy)-acetic acid is prepared by reacting a 2,3-dichloroanisole or 2 3-dichlorophenoxy- acetic acid or ester with a suitable .alpha.-haloacylhalide or .beta.-haloacylhalide under Friedel-Crafts conditions to form an intermediate acylation product which undergoes dehydro- halogenation in the side chain followed by ring closure to give an intermediate or the desired 2-substituted indanone. This latter compound is alkylated with a methylating or arylating agent to give the desired indanone. Several novel intermediates are also claimed.

210646

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