Process for the preparation of 1-pyridyl-alkyl-4-aryl...

Details Process for the preparation of 1-pyridyl-alkyl-4-aryl... Process for the preparation of 1-pyridyl-alkyl-4-aryl...

C - Chemistry, Metallurgy

07

D

260/266.3

C07D 401/06 (2006.01) C07D 213/36 (2006.01)

Patent

CA 1263959

ABSTRACT OF THE DISCLOSURE The present invention provides a process for the sepa- ration of the optical antipodes of the compound of the formula: Image (I) wherein P is ? , .beta. or .gamma. pyridyl, R is H; or CnH2n+1, n being a number from 1 to 4; and R' is H, halogen, CH3, OCH3 in which in process a) the racemic alcoholic derivative corresponding to the formula: Image (?)II is reacted with the chloride of the optically active acetylman- delic acid; b) the diastereoisomeric compound of the formula Image (+,L)III (-,D)III so obtained is hydrolyzed with hydroalcoholic KOH at room temper- ature; and when required c) the optically active alcoholic derivative of the formula Image (+)II (-)II so obtained after salification with alkaline hydrides or hydrox- ides in a solvent medium is treated with alkylating agents.

575394

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